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Implantable Pulmonary Artery Banding for Congenital Heart Disease

Congenital heart diseases (CHD) affect nearly 1% of – or about 40,000 – births per year in the United States. Among them, about 25% of newborns are in critical condition and need surgery or other procedures in the first year of life. Pulmonary artery banding (PAB) is a palliative surgical operation for patients with congenital heart disease suffering from pulmonary hypertension.

The objective of this work is to design, fabricate, and test advanced implantable pulmonary artery banding (PAB) for infants suffering from congenital heart disease.  The proposed design aims to address the need for a bio-compatible and compact artery banding (< 1mm diameter) capable of telemetric adjustment for both infant and lab animals with micrometer precision.

3D view of the telemetrically adjustable PAB device.Schematic 3D view of the telemetrically adjustable PAB device.

This novel battery-less device utilizes radio frequency (RF) excitation for wireless energy transfer and a pair of magnetically-driven micro-actuators with suspended doubly-clamped polymeric beams for clamping. Multiphysics finite element simulations are used for design and optimization. The proposed implant is 0.97 cm3 in size achieving 50% artery restriction or a total of 500 µm of displacement using maximum 100 mA  per coil. The PAB discussed in this paper is suitable for small infants less than 3kg in weight. Moreover, due to its small size, the device enables in vivo medical research on lab animals. The PAB device can be made using microfabrication techniques.

© Prof. Nima Ghalichechian's Group

Related paper: B. P. Lough, B. Ghassemiparvin, and N. Ghalichechian, “RF Micro-Electro-Mechanical Pulmonary Artery Banding for Congenital Heart Diseases”, IEEE 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, FL, USA, August 17-20, 2016.